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DNA sequencing has played a significant role in research study: de novo sequencing, which identifies new species; re-sequencing, in which sequencing individual after species reference sequences is already known. It is applied to all kinds of animals and plants. For human genome project, Human whole genome sequencing and exome sequencing are widely used in human medical researches.
DNA methylation alters gene expression in cells, which plays an important role in the development of cancer, neurodegenerative diseases and neurological diseases. There are 3 research methods to study DNA methylation: WGBS, RRBS, MeDIP-Seq. To study histone modification, ChIP-Seq is widely used.
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